Abstract
A novel series of cis-fused 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepin derivatives modified at position C-11 was prepared and evaluated for its potential antidepressant/anxiolytic properties. In vitro affinities for the norepinephrine transporter and for 5-HT(2A) and 5-HT(2C) receptors, as well as the ED(50) values obtained in some in vivo assays predictive for antidepressant and anxiolytic potential are reported.
MeSH terms
-
Benzofurans / chemical synthesis*
-
Benzofurans / pharmacology*
-
Norepinephrine / antagonists & inhibitors
-
Norepinephrine / metabolism*
-
Norepinephrine Plasma Membrane Transport Proteins
-
Oxepins / chemical synthesis*
-
Oxepins / pharmacology*
-
Serotonin 5-HT2 Receptor Antagonists*
-
Serotonin Antagonists / chemistry*
-
Serotonin Antagonists / pharmacology*
-
Symporters / antagonists & inhibitors
Substances
-
2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo(b,f)furo(2,3-d)oxepin
-
Benzofurans
-
Norepinephrine Plasma Membrane Transport Proteins
-
Oxepins
-
Serotonin 5-HT2 Receptor Antagonists
-
Serotonin Antagonists
-
Symporters
-
Norepinephrine